Quantitative approaches to uncover physical mechanisms of tissue morphogenesis

Jason P. Gleghorn, Sriram Manivannan, Celeste M. Nelson

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Morphogenesis, the creation of tissue and organ architecture, is a series of complex and dynamic processes driven by genetic programs, microenvironmental cues, and intercellular interactions. Elucidating the physical mechanisms that generate tissue form is key to understanding development, disease, and the strategies needed for regenerative therapies. Advancements in imaging technologies, genetic recombination techniques, laser ablation, and microfabricated tissue models have enabled quantitative descriptions of the cellular motions and tissue deformations and stresses with unprecedented temporal and spatial resolution. Using these data synergistically with increasingly more sophisticated physical, mathematical, and computational models will unveil the physical mechanisms that drive morphogenesis.

Original languageEnglish (US)
Pages (from-to)954-961
Number of pages8
JournalCurrent Opinion in Biotechnology
Volume24
Issue number5
DOIs
StatePublished - Oct 2013

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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