TY - JOUR
T1 - Quantitative approaches to uncover physical mechanisms of tissue morphogenesis
AU - Gleghorn, Jason P.
AU - Manivannan, Sriram
AU - Nelson, Celeste M.
N1 - Funding Information:
We apologize to colleagues whose work could not be discussed owing to space limitations. Work from the authors’ lab was supported in part by grants from the NIH ( GM083997 and HL110335 ), the David & Lucile Packard Foundation , the Alfred P. Sloan Foundation , Susan G. Komen for the Cure, and the Camille & Henry Dreyfus Foundation . C.M.N. holds a Career Award at the Scientific Interface from the Burroughs Wellcome Fund .
PY - 2013/10
Y1 - 2013/10
N2 - Morphogenesis, the creation of tissue and organ architecture, is a series of complex and dynamic processes driven by genetic programs, microenvironmental cues, and intercellular interactions. Elucidating the physical mechanisms that generate tissue form is key to understanding development, disease, and the strategies needed for regenerative therapies. Advancements in imaging technologies, genetic recombination techniques, laser ablation, and microfabricated tissue models have enabled quantitative descriptions of the cellular motions and tissue deformations and stresses with unprecedented temporal and spatial resolution. Using these data synergistically with increasingly more sophisticated physical, mathematical, and computational models will unveil the physical mechanisms that drive morphogenesis.
AB - Morphogenesis, the creation of tissue and organ architecture, is a series of complex and dynamic processes driven by genetic programs, microenvironmental cues, and intercellular interactions. Elucidating the physical mechanisms that generate tissue form is key to understanding development, disease, and the strategies needed for regenerative therapies. Advancements in imaging technologies, genetic recombination techniques, laser ablation, and microfabricated tissue models have enabled quantitative descriptions of the cellular motions and tissue deformations and stresses with unprecedented temporal and spatial resolution. Using these data synergistically with increasingly more sophisticated physical, mathematical, and computational models will unveil the physical mechanisms that drive morphogenesis.
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U2 - 10.1016/j.copbio.2013.04.006
DO - 10.1016/j.copbio.2013.04.006
M3 - Review article
C2 - 23647971
AN - SCOPUS:84884414816
SN - 0958-1669
VL - 24
SP - 954
EP - 961
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
IS - 5
ER -