Quantifying Current Events Identifies a Novel Endurance Regulator

Theresa C. Henry; Mark P. Brynildsen

doi:10.1016/j.tim.2016.02.014

Quantifying Current Events Identifies a Novel Endurance Regulator

Research output: Contribution to journal › Short survey › peer-review

Abstract

In nongrowing microbes, proteome turnover is reduced and identification of newly synthesized, low-abundance proteins is challenging. Babin and colleagues recently utilized bio-orthogonal noncanonical amino acid tagging (BONCAT) to identify actively synthesized proteins in nongrowing Pseudomonas aeruginosa, discovering a regulator whose influences range from biofilm formation to secondary metabolism.

Original language	English (US)
Pages (from-to)	324-326
Number of pages	3
Journal	Trends in Microbiology
Volume	24
Issue number	5
DOIs	https://doi.org/10.1016/j.tim.2016.02.014
State	Published - May 1 2016

All Science Journal Classification (ASJC) codes

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

Keywords

BONCAT
Nongrowing cells
Pseudomonas aeruginosa
SutA
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10.1016/j.tim.2016.02.014

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title = "Quantifying Current Events Identifies a Novel Endurance Regulator",

abstract = "In nongrowing microbes, proteome turnover is reduced and identification of newly synthesized, low-abundance proteins is challenging. Babin and colleagues recently utilized bio-orthogonal noncanonical amino acid tagging (BONCAT) to identify actively synthesized proteins in nongrowing Pseudomonas aeruginosa, discovering a regulator whose influences range from biofilm formation to secondary metabolism.",

keywords = "BONCAT, Nongrowing cells, Pseudomonas aeruginosa, SutA, Transcription",

author = "Henry, {Theresa C.} and Brynildsen, {Mark P.}",

note = "Funding Information: This work was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (T.C.H.; F30AI114163) and Princeton University (M.P.B.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.",

year = "2016",

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doi = "10.1016/j.tim.2016.02.014",

language = "English (US)",

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journal = "Trends in Microbiology",

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TY - JOUR

T1 - Quantifying Current Events Identifies a Novel Endurance Regulator

AU - Henry, Theresa C.

AU - Brynildsen, Mark P.

N1 - Funding Information: This work was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (T.C.H.; F30AI114163) and Princeton University (M.P.B.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - In nongrowing microbes, proteome turnover is reduced and identification of newly synthesized, low-abundance proteins is challenging. Babin and colleagues recently utilized bio-orthogonal noncanonical amino acid tagging (BONCAT) to identify actively synthesized proteins in nongrowing Pseudomonas aeruginosa, discovering a regulator whose influences range from biofilm formation to secondary metabolism.

AB - In nongrowing microbes, proteome turnover is reduced and identification of newly synthesized, low-abundance proteins is challenging. Babin and colleagues recently utilized bio-orthogonal noncanonical amino acid tagging (BONCAT) to identify actively synthesized proteins in nongrowing Pseudomonas aeruginosa, discovering a regulator whose influences range from biofilm formation to secondary metabolism.

KW - BONCAT

KW - Nongrowing cells

KW - Pseudomonas aeruginosa

KW - SutA

KW - Transcription

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U2 - 10.1016/j.tim.2016.02.014

DO - 10.1016/j.tim.2016.02.014

M3 - Short survey

C2 - 26954590

AN - SCOPUS:84959285627

SN - 0966-842X

VL - 24

SP - 324

EP - 326

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 5

ER -

Quantifying Current Events Identifies a Novel Endurance Regulator

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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