PyFluor: A low-cost, stable, and selective deoxyfluorination reagent

Matthew K. Nielsen; Christian R. Ugaz; Wenping Li; Abigail G. Doyle

doi:10.1021/jacs.5b06307

PyFluor: A low-cost, stable, and selective deoxyfluorination reagent

Matthew K. Nielsen, Christian R. Ugaz, Wenping Li, Abigail G. Doyle

Research output: Contribution to journal › Article › peer-review

241 Scopus citations

Abstract

We report an inexpensive, thermally stable deoxyfluorination reagent that fluorinates a broad range of alcohols without substantial formation of elimination side products. This combination of selectivity, safety, and economic viability enables deoxyfluorination on preparatory scale. We employ the [¹⁸F]-labeled reagent in the first example of a no-carrier-added deoxy-radiofluorination.

Original language	English (US)
Pages (from-to)	9571-9574
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	137
Issue number	30
DOIs	https://doi.org/10.1021/jacs.5b06307
State	Published - Aug 5 2015

All Science Journal Classification (ASJC) codes

General Chemistry
Biochemistry
Catalysis
Colloid and Surface Chemistry

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10.1021/jacs.5b06307

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abstract = "We report an inexpensive, thermally stable deoxyfluorination reagent that fluorinates a broad range of alcohols without substantial formation of elimination side products. This combination of selectivity, safety, and economic viability enables deoxyfluorination on preparatory scale. We employ the [18F]-labeled reagent in the first example of a no-carrier-added deoxy-radiofluorination.",

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AU - Ugaz, Christian R.

AU - Li, Wenping

AU - Doyle, Abigail G.

PY - 2015/8/5

Y1 - 2015/8/5

N2 - We report an inexpensive, thermally stable deoxyfluorination reagent that fluorinates a broad range of alcohols without substantial formation of elimination side products. This combination of selectivity, safety, and economic viability enables deoxyfluorination on preparatory scale. We employ the [18F]-labeled reagent in the first example of a no-carrier-added deoxy-radiofluorination.

AB - We report an inexpensive, thermally stable deoxyfluorination reagent that fluorinates a broad range of alcohols without substantial formation of elimination side products. This combination of selectivity, safety, and economic viability enables deoxyfluorination on preparatory scale. We employ the [18F]-labeled reagent in the first example of a no-carrier-added deoxy-radiofluorination.

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AN - SCOPUS:84938820331

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ER -

PyFluor: A low-cost, stable, and selective deoxyfluorination reagent

Abstract

All Science Journal Classification (ASJC) codes

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