PyFluor: A low-cost, stable, and selective deoxyfluorination reagent

Matthew K. Nielsen, Christian R. Ugaz, Wenping Li, Abigail G. Doyle

Research output: Contribution to journalArticlepeer-review

194 Scopus citations


We report an inexpensive, thermally stable deoxyfluorination reagent that fluorinates a broad range of alcohols without substantial formation of elimination side products. This combination of selectivity, safety, and economic viability enables deoxyfluorination on preparatory scale. We employ the [18F]-labeled reagent in the first example of a no-carrier-added deoxy-radiofluorination.

Original languageEnglish (US)
Pages (from-to)9571-9574
Number of pages4
JournalJournal of the American Chemical Society
Issue number30
StatePublished - Aug 5 2015

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biochemistry
  • Catalysis
  • Colloid and Surface Chemistry


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