PyFluor: A low-cost, stable, and selective deoxyfluorination reagent

Matthew K. Nielsen; Christian R. Ugaz; Wenping Li; Abigail G. Doyle

doi:10.1021/jacs.5b06307

PyFluor: A low-cost, stable, and selective deoxyfluorination reagent

Matthew K. Nielsen, Christian R. Ugaz, Wenping Li, Abigail G. Doyle

Research output: Contribution to journal › Article › peer-review

203 Scopus citations

Abstract

We report an inexpensive, thermally stable deoxyfluorination reagent that fluorinates a broad range of alcohols without substantial formation of elimination side products. This combination of selectivity, safety, and economic viability enables deoxyfluorination on preparatory scale. We employ the [¹⁸F]-labeled reagent in the first example of a no-carrier-added deoxy-radiofluorination.

Original language	English (US)
Pages (from-to)	9571-9574
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	137
Issue number	30
DOIs	https://doi.org/10.1021/jacs.5b06307
State	Published - Aug 5 2015

All Science Journal Classification (ASJC) codes

General Chemistry
Biochemistry
Catalysis
Colloid and Surface Chemistry

Access to Document

10.1021/jacs.5b06307

Cite this

@article{2fd6fba366d14344beffccfff0728b0f,

title = "PyFluor: A low-cost, stable, and selective deoxyfluorination reagent",

abstract = "We report an inexpensive, thermally stable deoxyfluorination reagent that fluorinates a broad range of alcohols without substantial formation of elimination side products. This combination of selectivity, safety, and economic viability enables deoxyfluorination on preparatory scale. We employ the [18F]-labeled reagent in the first example of a no-carrier-added deoxy-radiofluorination.",

author = "Nielsen, {Matthew K.} and Ugaz, {Christian R.} and Wenping Li and Doyle, {Abigail G.}",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = aug,

day = "5",

doi = "10.1021/jacs.5b06307",

language = "English (US)",

volume = "137",

pages = "9571--9574",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "30",

}

TY - JOUR

T1 - PyFluor

T2 - A low-cost, stable, and selective deoxyfluorination reagent

AU - Nielsen, Matthew K.

AU - Ugaz, Christian R.

AU - Li, Wenping

AU - Doyle, Abigail G.

PY - 2015/8/5

Y1 - 2015/8/5

N2 - We report an inexpensive, thermally stable deoxyfluorination reagent that fluorinates a broad range of alcohols without substantial formation of elimination side products. This combination of selectivity, safety, and economic viability enables deoxyfluorination on preparatory scale. We employ the [18F]-labeled reagent in the first example of a no-carrier-added deoxy-radiofluorination.

AB - We report an inexpensive, thermally stable deoxyfluorination reagent that fluorinates a broad range of alcohols without substantial formation of elimination side products. This combination of selectivity, safety, and economic viability enables deoxyfluorination on preparatory scale. We employ the [18F]-labeled reagent in the first example of a no-carrier-added deoxy-radiofluorination.

UR - http://www.scopus.com/inward/record.url?scp=84938820331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938820331&partnerID=8YFLogxK

U2 - 10.1021/jacs.5b06307

DO - 10.1021/jacs.5b06307

M3 - Article

C2 - 26177230

AN - SCOPUS:84938820331

SN - 0002-7863

VL - 137

SP - 9571

EP - 9574

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 30

ER -

PyFluor: A low-cost, stable, and selective deoxyfluorination reagent

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this