TY - JOUR
T1 - PVP1—The People’s Ventilator Project
T2 - A fully open, low-cost, pressure-controlled ventilator research platform compatible with adult and pediatric uses
AU - LaChance, Julienne
AU - Schottdorf, Manuel
AU - Zajdel, Tom J.
AU - Saunders, Jonny L.
AU - Dvali, Sophie
AU - Marshall, Chase
AU - Seirup, Lorenzo
AU - Sammour, Ibrahim
AU - Chatburn, Robert L.
AU - Notterman, Daniel A.
AU - Cohen, Daniel J.
N1 - Funding Information:
This work was supported by Princeton University which provided funding and facilities. In addition, JLS is supported by NSF Graduate Research Fellowship No. 1309047. TJZ was supported by the National Center for Advancing Translational Sciences (NCATS), a component of the National Institute of Health (NIH) under award number TL1TR003019. The sponsors and funders did not play any role in the study design, data collection and analysis, decision to publish, and preparation of the manuscript. We would like to thank Grant Wallace, Zhenyu Song, Moritz Kütt and Philippe Bourrianne for very valuable discussions and technical support during the development of PVP1, and Amy Sterling, the EyeWire team, and Sebastian Seung for their help and guidance in building a PVP1 community. In addition, we would like to thank Elad Hazan and Daniel Suo with the Google AI team at Princeton for testing the quality of PVP1’s build instructions. We would also like to acknowledge the contribution of the open science community as a whole, by providing guidelines, standards and tools. Disclaimer: PVP1 is not a regulated or clinically validated medical device. We have not yet performed testing for safety or efficacy on living organisms. All material described herein should be used at your own risk and does not represent a medical recommendation. PVP1 is currently recommended only for research purposes. This document is not connected to, endorsed by, or representative of the view of Princeton University. Neither the authors nor Princeton University assume any liability or responsibility for any consequences, damages, or loss caused or alleged to be caused directly or indirectly for any action or inaction taken based on or made in reliance on the information or material discussed herein. PVP1 is under continuous development and the information here may not be up to date, nor is any guarantee made as such. Neither the authors nor Princeton University are liable for any damage or loss related to the accuracy, completeness or timeliness of any information describe or linked to from this website.
Publisher Copyright:
Copyright: © 2022 LaChance et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2022/5
Y1 - 2022/5
N2 - Mechanical ventilators are safety-critical devices that help patients breathe, commonly found in hospital intensive care units (ICUs)—yet, the high costs and proprietary nature of commercial ventilators inhibit their use as an educational and research platform. We present a fully open ventilator device—The People’s Ventilator: PVP1—with complete hardware and software documentation including detailed build instructions and a DIY cost of $1,700 USD. We validate PVP1 against both key performance criteria specified in the U.S. Food and Drug Administration’s Emergency Use Authorization for Ventilators, and in a pediatric context against a state-of-the-art commercial ventilator. Notably, PVP1 performs well over a wide range of test conditions and performance stability is demonstrated for a minimum of 75,000 breath cycles over three days with an adult mechanical test lung. As an open project, PVP1 can enable future educational, academic, and clinical developments in the ventilator space.
AB - Mechanical ventilators are safety-critical devices that help patients breathe, commonly found in hospital intensive care units (ICUs)—yet, the high costs and proprietary nature of commercial ventilators inhibit their use as an educational and research platform. We present a fully open ventilator device—The People’s Ventilator: PVP1—with complete hardware and software documentation including detailed build instructions and a DIY cost of $1,700 USD. We validate PVP1 against both key performance criteria specified in the U.S. Food and Drug Administration’s Emergency Use Authorization for Ventilators, and in a pediatric context against a state-of-the-art commercial ventilator. Notably, PVP1 performs well over a wide range of test conditions and performance stability is demonstrated for a minimum of 75,000 breath cycles over three days with an adult mechanical test lung. As an open project, PVP1 can enable future educational, academic, and clinical developments in the ventilator space.
UR - http://www.scopus.com/inward/record.url?scp=85129961886&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85129961886&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0266810
DO - 10.1371/journal.pone.0266810
M3 - Article
C2 - 35544461
AN - SCOPUS:85129961886
SN - 1932-6203
VL - 17
JO - PLoS One
JF - PLoS One
IS - 5 May
M1 - e0266810
ER -