@inbook{b31f5bae53404bd4915e6bec24cd5dda,
title = "Putting in the Erk: Growth factor signaling and mesoderm morphogenesis",
abstract = "It has long been known that FGF signaling contributes to mesoderm formation, a germ layer found in triploblasts that is composed of highly migratory cells that give rise to muscles and to the skeletal structures of vertebrates. FGF signaling activates several pathways in the developing mesoderm, including transient activation of the Erk pathway, which triggers mesodermal fate specification through the induction of the gene brachyury and activates morphogenetic programs that allow mesodermal cells to position themselves in the embryo. In this review, we discuss what is known about the generation and interpretation of transient Erk signaling in mesodermal tissues across species. We focus specifically on mechanisms that translate the level and duration of Erk signaling into cell fate and cell movement instructions and discuss strategies for further interrogating the role that Erk signaling dynamics play in mesodermal gastrulation and morphogenesis.",
keywords = "Differentiation, Erk, Mesoderm, Signaling dynamics",
author = "McFann, {Sarah E.} and Shvartsman, {Stanislav Y.} and Toettcher, {Jared E.}",
note = "Funding Information: The authors thank members of the Shvartsman and Toettcher laboratories for insightful discussions, as well as the broader developmental signaling community for its support. We apologize to the authors of many excellent studies that we were unable to discuss and cite for brevity. The writing of this review was supported by Hertz Fellowship and the NSF Graduate Research Fellowship Program (S.E.M.) and National Science Foundation CAREER Award 1750663 (to J.E.T.). Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2022",
month = jan,
doi = "10.1016/bs.ctdb.2022.02.007",
language = "English (US)",
isbn = "9780128170977",
series = "Current Topics in Developmental Biology",
publisher = "Academic Press Inc.",
pages = "263--310",
editor = "Soriano, {Philippe M.}",
booktitle = "Cell Signaling Pathways in Development",
address = "United States",
}