Punishment promotes response control deficits in obsessive-compulsive disorder: Evidence from a motivational go/no-go task

S. Morein-Zamir, M. Papmeyer, C. M. Gillan, M. J. Crockett, N. A. Fineberg, B. J. Sahakian, T. W. Robbins

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Background Obsessive-compulsive disorder (OCD) has been associated with response inhibition deficits under motivationally neutral contingencies. We examined response inhibition performance in the presence of reward and punishment. We further investigated whether the hypothesized difficulties in flexibly updating behaviour based on external feedback in OCD would also lead to a reduced ability to adjust to changes in the reward and punishment contingencies. Method Participants completed a go/no-go task that used punishments or rewards to promote response activation or suppression. The task was administered to OCD patients free of current Axis-I co-morbidities including major depression (n = 20) and a group of healthy controls (n = 32). Results Compared with controls, patients with OCD had increased commission errors in punishment conditions, and failed to slow down immediately after receiving punishment. The punishment-induced increase in commission errors correlated with self-report measures of OCD symptom severity. Additionally, patients did not differ from controls in adapting their overall response style to the changes in task contingencies. Conclusions Individuals with OCD showed reduced response control selectively under punishment conditions, manifesting in an impulsive response style that was related to their current symptom severity. This stresses failures of cognitive control in OCD, particularly under negative motivational contingencies.

Original languageEnglish (US)
Pages (from-to)391-400
Number of pages10
JournalPsychological Medicine
Volume43
Issue number2
DOIs
StatePublished - Feb 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Applied Psychology

Keywords

  • Inhibition
  • obsessive-compulsive disorder
  • punishment
  • response control
  • reward

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