Abstract
(Equation Presented) The asymmetric Michael reaction of pseudoephedrine amides is reported. The 1,5-dicarbonyl products are converted to 3-aryl-δ-lactones in a two-step reduction/lactonization sequence. This method provides access to enantiomerically enriched trans-3,4-disubstituted δ-lactones.
Original language | English (US) |
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Pages (from-to) | 1963-1966 |
Number of pages | 4 |
Journal | Organic letters |
Volume | 4 |
Issue number | 11 |
DOIs | |
State | Published - May 30 2002 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry