Proteomics techniques and their application to hematology

Ileana M. Cristea, Simon J. Gaskell, Anthony D. Whetton

Research output: Contribution to journalReview article

90 Scopus citations

Abstract

The recent sequencing of a number of genomes has raised the level of opportunities for studies on proteins. This area of research has been described with the all-embracing term, proteomics. In proteomics, the use of mass spectrometric techniques enables genomic databases to be used to establish the identity of proteins with relatively little data, compared to the era before genome sequencing. The use of related analytical techniques also offers the opportunity to gain information on regulation, via posttranslational modification, and potential new diagnostic and prognostic indicators. Relative quantification of proteins and peptides In cellular and extracellular material remains a challenge for proteomics and mass spectrometry. This review presents an analysis of the present and future Impact of these proteomic technologies with emphasis on relative quantification for hematologic research giving an appraisal of their potential benefits.

Original languageEnglish (US)
Pages (from-to)3624-3634
Number of pages11
JournalBlood
Volume103
Issue number10
DOIs
StatePublished - May 15 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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