Proteomics of nucleocytoplasmic partitioning

Thao Nguyen, Nishant Pappireddi, Martin Wühr

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

The partitioning of the proteome between nucleus and cytoplasm affects nearly every aspect of eukaryotic biology. Despite this central role, we still have a poor understanding of which proteins localize in the nucleus and how this varies in different cell types and conditions. Recent advances in quantitative proteomics and high-throughput imaging are starting to close this knowledge gap. Studies on protein interaction are beginning to reveal the spectrum of cargos of nuclear import and export receptors. We anticipate that it will soon be possible to predict each protein's nucleocytoplasmic localization based on its importin/exportin interactions and its estimated diffusion rate through the nuclear pore. This insight is likely to provide us with a fundamental understanding of how cells use nucleocytoplasmic partitioning to encode and relay information.

Original languageEnglish (US)
Pages (from-to)55-63
Number of pages9
JournalCurrent Opinion in Chemical Biology
Volume48
DOIs
StatePublished - Feb 2019

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry

Fingerprint Dive into the research topics of 'Proteomics of nucleocytoplasmic partitioning'. Together they form a unique fingerprint.

  • Cite this