Proteolytic ratchets that control progression through mitosis

Fiona M. Townsley; Joan V. Ruderman

doi:10.1016/S0962-8924(98)01268-9

Proteolytic ratchets that control progression through mitosis

Fiona M. Townsley
, Joan V. Ruderman

Research output: Contribution to journal › Review article › peer-review

109 Scopus citations

Abstract

A key player in mitotic progression is a cell-cycle-regulated ubiquitin-protein ligase complex known as the anaphase-promoting complex or cyclosome (APC/C). The APC/C is part of the machinery that promotes the metaphase-anaphase transition by mediating the ubiquitin-dependent destruction of anaphase inhibitors and initiates exit from mitosis by degrading mitotic cyclins. This review describes the known components and substrates of the mitotic ubiquitination machinery and discusses how a new subfamily of proteins that contain the WD40 repeat (the Fizzy/Cdc20p family) might activate the APC/C to allow temporal differences in substrate ubiquitination during progression through mitosis.

Original language	English (US)
Pages (from-to)	238-244
Number of pages	7
Journal	Trends in Cell Biology
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/S0962-8924(98)01268-9
State	Published - Jun 1 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1016/S0962-8924(98)01268-9

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title = "Proteolytic ratchets that control progression through mitosis",

abstract = "A key player in mitotic progression is a cell-cycle-regulated ubiquitin-protein ligase complex known as the anaphase-promoting complex or cyclosome (APC/C). The APC/C is part of the machinery that promotes the metaphase-anaphase transition by mediating the ubiquitin-dependent destruction of anaphase inhibitors and initiates exit from mitosis by degrading mitotic cyclins. This review describes the known components and substrates of the mitotic ubiquitination machinery and discusses how a new subfamily of proteins that contain the WD40 repeat (the Fizzy/Cdc20p family) might activate the APC/C to allow temporal differences in substrate ubiquitination during progression through mitosis.",

author = "Townsley, \{Fiona M.\} and Ruderman, \{Joan V.\}",

year = "1998",

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doi = "10.1016/S0962-8924(98)01268-9",

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T1 - Proteolytic ratchets that control progression through mitosis

AU - Townsley, Fiona M.

AU - Ruderman, Joan V.

PY - 1998/6/1

Y1 - 1998/6/1

N2 - A key player in mitotic progression is a cell-cycle-regulated ubiquitin-protein ligase complex known as the anaphase-promoting complex or cyclosome (APC/C). The APC/C is part of the machinery that promotes the metaphase-anaphase transition by mediating the ubiquitin-dependent destruction of anaphase inhibitors and initiates exit from mitosis by degrading mitotic cyclins. This review describes the known components and substrates of the mitotic ubiquitination machinery and discusses how a new subfamily of proteins that contain the WD40 repeat (the Fizzy/Cdc20p family) might activate the APC/C to allow temporal differences in substrate ubiquitination during progression through mitosis.

AB - A key player in mitotic progression is a cell-cycle-regulated ubiquitin-protein ligase complex known as the anaphase-promoting complex or cyclosome (APC/C). The APC/C is part of the machinery that promotes the metaphase-anaphase transition by mediating the ubiquitin-dependent destruction of anaphase inhibitors and initiates exit from mitosis by degrading mitotic cyclins. This review describes the known components and substrates of the mitotic ubiquitination machinery and discusses how a new subfamily of proteins that contain the WD40 repeat (the Fizzy/Cdc20p family) might activate the APC/C to allow temporal differences in substrate ubiquitination during progression through mitosis.

UR - https://www.scopus.com/pages/publications/0032101245

UR - https://www.scopus.com/pages/publications/0032101245#tab=citedBy

U2 - 10.1016/S0962-8924(98)01268-9

DO - 10.1016/S0962-8924(98)01268-9

M3 - Review article

C2 - 9695848

AN - SCOPUS:0032101245

SN - 0962-8924

VL - 8

SP - 238

EP - 244

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 6

ER -

Proteolytic ratchets that control progression through mitosis

Abstract

All Science Journal Classification (ASJC) codes

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