Protein dynamics implications of the low- And high-temperature denaturation of myoglobin

Ramzi R. Khuri, Trung V. Phan, Robert H. Austin

Research output: Contribution to journalArticlepeer-review

Abstract

We reinvestigate a simple model used in the literature concerning the thermodynamic analysis of protein cold denaturation. We derive an exact thermodynamic expression for cold denaturation and give a better approximation than exists in the literature for predicting cold denaturation temperatures in the two-state model. We discuss the “dark-side” implications of this work for previous temperature-dependent protein dynamics experiments and discuss microfluidic experimental technologies, which could explore the thermal stability range of proteins below the bulk freezing point of water.

Original languageEnglish (US)
Article number034414
JournalPhysical Review E
Volume104
Issue number3
DOIs
StatePublished - Sep 2021

All Science Journal Classification (ASJC) codes

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

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