Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product

Matthias Dobbelstein, Thomas Shenk

Research output: Contribution to journalArticlepeer-review

132 Scopus citations

Abstract

Vaccinia virus contains a gene, termed SPI-2 or B13R, that is closely related in its sequence to a potent inhibitor of apoptosis from cowpox virus (crmA). Infection by vaccinia virus protects HeLa cells against apoptosis that is induced by an immunoglobulin M antibody against the fas receptor or by tumor necrosis factor alpha. This effect is profoundly reduced when the SPI-2 gene is deleted. The SPI-2 gene, when transiently expressed in these cells, can also protect against apoptosis mediated by these agents. Given the similarity to crmA, it seems likely that SPI-2 functions in an analogous fashion, inhibiting the activity of ICE protease family members and blocking the onset of apoptosis.

Original languageEnglish (US)
Pages (from-to)6479-6485
Number of pages7
JournalJournal of virology
Volume70
Issue number9
DOIs
StatePublished - Sep 1996

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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