Prospecting genomes for lasso peptides

Mikhail O. Maksimov, A. James Link

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

Genome mining has unlocked a veritable treasure chest of natural compounds. However, each family of natural products requires a genome-mining approach tailored to its unique features to be successful. Lasso peptides are ribosomally synthesized and posttranslationally modified products with a unique three-dimensional structure. Advances in the understanding of these molecules have informed the design of strategies to identify new members of the class in sequenced genomes. This review presents the bioinformatic methods used to discover novel lasso peptides and describes how such analyses have afforded insights into the biosynthesis and evolution of this peptide class.

Original languageEnglish (US)
Pages (from-to)333-344
Number of pages12
JournalJournal of Industrial Microbiology and Biotechnology
Volume41
Issue number2
DOIs
StatePublished - Feb 2014

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Keywords

  • Genome mining
  • Lasso peptides
  • RiPPs

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