Properties of developmental gene regulatory networks

Eric H. Davidson, Michael S. Levine

Research output: Contribution to journalReview articlepeer-review

152 Scopus citations

Abstract

The modular components, or subcircuits, of developmental gene regulatory networks (GRNs) execute specific developmental functions, such as the specification of cell identity. We survey examples of such subcircuits and relate their structures to corresponding developmental functions. These relations transcend organisms and genes, as illustrated by the similar structures of the subcircuits controlling the specification of the mesectoderm in the Drosophila embryo and the endomesoderm in the sea urchin, even though the respective subcircuits are composed of nonorthologous regulatory genes.

Original languageEnglish (US)
Pages (from-to)20063-20066
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume105
Issue number51
DOIs
StatePublished - Dec 23 2008

All Science Journal Classification (ASJC) codes

  • General

Keywords

  • Drosophila development
  • Genomic regulatory logic
  • Regulatory subcircuits
  • Sea urchin development

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