Abstract
The modular components, or subcircuits, of developmental gene regulatory networks (GRNs) execute specific developmental functions, such as the specification of cell identity. We survey examples of such subcircuits and relate their structures to corresponding developmental functions. These relations transcend organisms and genes, as illustrated by the similar structures of the subcircuits controlling the specification of the mesectoderm in the Drosophila embryo and the endomesoderm in the sea urchin, even though the respective subcircuits are composed of nonorthologous regulatory genes.
Original language | English (US) |
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Pages (from-to) | 20063-20066 |
Number of pages | 4 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 105 |
Issue number | 51 |
DOIs | |
State | Published - Dec 23 2008 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General
Keywords
- Drosophila development
- Genomic regulatory logic
- Regulatory subcircuits
- Sea urchin development