@article{1a05b5d5594f42a6a6393c27aaf3e177,
title = "Promoting validation and cross-phylogenetic integration in model organism research",
abstract = "Model organism (MO) research provides a basic understanding of biology and disease due to the evolutionary conservation of the molecular and cellular language of life. MOs have been used to identify and understand the function of orthologous genes, proteins, cells and tissues involved in biological processes, to develop and evaluate techniques and methods, and to perform whole-organismbased chemical screens to test drug efficacy and toxicity. However, a growing richness of datasets and the rising power of computation raise an important question: How do we maximize the value of MOs? In-depth discussions in over 50 virtual presentations organized by the National Institutes of Health across more than 10 weeks yielded important suggestions for improving the rigor, validation, reproducibility and translatability of MO research. The effort clarified challenges and opportunities for developing and integrating tools and resources. Maintenance of critical existing infrastructure and the implementation of suggested improvements will play important roles in maintaining productivity and facilitating the validation of animal models of human biology and disease.",
keywords = "Human diseases, Integration, Model organisms, Omics, Phenomics, Research resources, Technology, Validation",
author = "Cheng, {Keith C.} and Burdine, {Rebecca D.} and Dickinson, {Mary E.} and Ekker, {Stephen C.} and Lin, {Alex Y.} and Lloyd, {K. C.Kent} and Lutz, {Cathleen M.} and MacRae, {Calum A.} and Morrison, {John H.} and O'Connor, {David H.} and Postlethwait, {John H.} and Rogers, {Crystal D.} and Susan Sanchez and Simpson, {Julie H.} and Talbot, {William S.} and Wallace, {Douglas C.} and Weimer, {Jill M.} and Bellen, {Hugo J.}",
note = "Funding Information: Support was provided by the Office of Extramural Research, National Institutes of Health (R24 OD18559 to K.C.C.), the National Institutes of Health (R01 AR071486 to R.D.B.; UM1 HG006348, U42 OD026645, U54 OD030165 and R03 OD030597 to M.E.D.; R01 GM063904 to S.C.E.; by U42 OD012210, UM1 OD023221 and U2C DK092993 to K.C.K.L.; R24 OD017870 and U54 NS079201 to C.A.M.; P51 OD011107 to J.H.M.; R24 OD026591 and R01 OD011116 to J.H.P.; R01 NS110866 and R21 NS114618 to J.H.S.; R35 NS111584 to W.S.T.; U54 NS093793, R24 OD022005 and R24 OD031447 to H.J.B.) and Howard Hughes Medical Institute (to H.J.B.). Funding Information: This article represents insights gained during a series of ten workshops and other discussions initially organized by the NIH Office of Research Infrastructure Programs (ORIP) in collaboration with the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Aging (NIA), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute of General Medical Sciences (NIGMS), and the National Institute of Neurological Disorders and Stroke (NINDS), entitled {\textquoteleft}Virtual Workshops on Validation of Animal Models and Tools for Biomedical Research{\textquoteright} and held in 2020 and 2021. We thank Dr Sige Zou at ORIP, who worked with program staff at ORIP, NHLBI, NIA, NIDDK, NIGMS and NINDS to organize the workshops with co-chairs H.J.B. and K.C.C. We also thank Dr Shinya Yamamoto for generating Fig. 1, and Dr Shinya Yamamoto and Dr Oguz Kanca for valuable comments. Publisher Copyright: {\textcopyright} 2022. Published by The Company of Biologists Ltd.",
year = "2022",
month = sep,
doi = "10.1242/dmm.049600",
language = "English (US)",
volume = "15",
journal = "DMM Disease Models and Mechanisms",
issn = "1754-8403",
publisher = "Company of Biologists Ltd",
number = "9",
}