Progress in single-molecule spectroscopy in cells

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Time-dependent single-molecule spectroscopy allows the direct observation of molecular processes in real time, capturing transient and stochastic events that cannot be detected using conventional ensemble-averaged methods. It offers a promising approach to uncovering the physical and chemical transformations underlying cellular responses. Recent advances in the probe development, specific labeling strategies, and spectroscopy instrumentation suggest the feasibility of monitoring a single molecular machine's actions inside a living cell.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalCurrent Opinion in Chemical Biology
Issue number1
StatePublished - Feb 2010

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry


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