Progress in Epigenetics of Depression

Catherine J. Peña, Eric J. Nestler

Research output: Chapter in Book/Report/Conference proceedingChapter

57 Scopus citations


Depression is a prevalent and complex psychiatric syndrome. Epigenetic mechanisms bridge the genetic and environmental factors that contribute to the pathophysiology of depression. A surge of research over the last decade has identified changes in DNA methylation, histone modifications, histone organization, and noncoding RNAs associated with depression and stress-induced depression-like behavior in animal models. We focus here on associations of epigenetic factors concurrent with depression and depression-like behavior, although risk for depression and some of the associated epigenetic changes are known to have developmental origins. Finally, emerging technology may enable breakthroughs in the ability to rescue depression-associated epigenetic modifications at specific genes, greatly enhancing specificity of future potential therapeutic treatments.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Number of pages26
StatePublished - 2018
Externally publishedYes

Publication series

NameProgress in Molecular Biology and Translational Science
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology


  • DNA methylation
  • depression
  • epigenetic mechanisms
  • histone modifications
  • noncoding RNAs


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