Probing the kinesin reaction cycle with a 2D optical force clamp

C. L. Asbury, J. W. Shaevitz, M. J. Lang, S. M. Block

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We developed an optical force clamp to apply loads to single molecules of kinesin moving on microtubule filaments. The effects of forward, backward, and sideways loads on kinesin motion suggest that the underlying reaction cycle contains a single working stroke that is well aligned with the direction of motion.

Original languageEnglish (US)
Title of host publicationFrontiers in Optics, FiO 2003
PublisherOptica Publishing Group (formerly OSA)
ISBN (Electronic)1557527598
StatePublished - 2003
Externally publishedYes
EventFrontiers in Optics, FiO 2003 - Tucson, United States
Duration: Oct 5 2003 → …

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701


ConferenceFrontiers in Optics, FiO 2003
Country/TerritoryUnited States
Period10/5/03 → …

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials


Dive into the research topics of 'Probing the kinesin reaction cycle with a 2D optical force clamp'. Together they form a unique fingerprint.

Cite this