Probing single-molecule dynamics photon by photon

Haw Yang, X. Sunney Xie

Research output: Contribution to journalArticlepeer-review

168 Scopus citations


The theoretical basis of new methods for studying single-molecule dynamics over the time scales of enzymatic importance is presented. As such, a general methodology that is based on fluctuation-correlation analysis of experimental observables photon by photon is introduced. This statistically efficient method not only extends the fast measurable time scale to a microsecond or less, but also allows the education of information from the limited number of detected photons of a single molecule over the time scales that are important in characterizing the function of a biological macromolecule.

Original languageEnglish (US)
Pages (from-to)10965-10979
Number of pages15
JournalJournal of Chemical Physics
Issue number24
StatePublished - Dec 22 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Physics and Astronomy
  • Physical and Theoretical Chemistry


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