Preparation of PEGylated Iodine-Loaded Nanoparticles via Polymer-Directed Self-Assembly

Christina Tang, Adam W. York, John L. Mikitsh, Alexander C. Wright, Ann Marie Chacko, Drew R. Elias, Yaodong Xu, Heng Keang Lim, Robert K. Prud'homme

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The preparation of size-tunable PEGylated, iodine-loaded nanoparticles is investigated for biomedical applications. Di-iodination of polyvinyl phenol and encapsulation of the iodinated polymer via directed self-assembly with an amphiphilic polyethylene glycol-based diblock copolymer are reported. Nanoparticles with iodine loadings up to 45 wt% are achieved using a rapid, scalable process. The size of the nanoparticles can be readily tuned between 35 and 130 nm by increasing the ionic strength of the antisolvent used during nanoparticle self-assembly. The resulting PEGylated iodine-loaded nanoparticles have potential applications in nanomedicine for 1) quantitative biodistribution analysis via inductively coupled plasma mass spectrometry (ICP-MS) or 2) X-ray contrast in biomedical imaging. For quantitative biodistribution studies using ICP-MS, a limit of detection of 2 µg mL−1 in mouse serum is achieved. For biomedical imaging, the X-ray attenuation rates are comparable to currently commercially available iodine-based contrast agents. Therefore, encapsulation of the iodinated polymer enables formulation of trackable, size tunable nanoparticles as a versatile platform for developing nanomedicines.

Original languageEnglish (US)
Article number1700592
JournalMacromolecular Chemistry and Physics
Volume219
Issue number11
DOIs
StatePublished - Jun 2018

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Keywords

  • amphiphiles
  • diblock copolymers
  • micelles
  • nanoparticles
  • self-assembly

Fingerprint Dive into the research topics of 'Preparation of PEGylated Iodine-Loaded Nanoparticles via Polymer-Directed Self-Assembly'. Together they form a unique fingerprint.

  • Cite this

    Tang, C., York, A. W., Mikitsh, J. L., Wright, A. C., Chacko, A. M., Elias, D. R., Xu, Y., Lim, H. K., & Prud'homme, R. K. (2018). Preparation of PEGylated Iodine-Loaded Nanoparticles via Polymer-Directed Self-Assembly. Macromolecular Chemistry and Physics, 219(11), [1700592]. https://doi.org/10.1002/macp.201700592