Preparation of aggregation stable block copolymer nanoparticles for simultaneous drug delivery and imaging

M. Gindy; Robert Krafft Prud'homme

Preparation of aggregation stable block copolymer nanoparticles for simultaneous drug delivery and imaging

M. Gindy, Robert Krafft Prud'homme

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We present a novel process for the simultaneous encapsulation of active pharmaceutical compounds (βcarotene, α-tocopherol succinate) and imaging agents (dodecanethiol gold nanoparticles and 7-amino-4-methyl coumarin) based on diblock copolymer self assembly in the diffusion limited regime. Uniform particles with tunable sizes from 50-300 nm and long term stability are prepared at high concentrations of incorporated compound. The degree of agent loading is varied independently of particle size, allowing for precise control of system parameters.

Original language	English (US)
Title of host publication	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Pages	448-450
Number of pages	3
Volume	2
State	Published - Dec 8 2006
Event	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States Duration: May 7 2006 → May 11 2006

Other

Other	2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Country/Territory	United States
City	Boston, MA
Period	5/7/06 → 5/11/06

All Science Journal Classification (ASJC) codes

Engineering(all)

Cite this

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title = "Preparation of aggregation stable block copolymer nanoparticles for simultaneous drug delivery and imaging",

abstract = "We present a novel process for the simultaneous encapsulation of active pharmaceutical compounds (βcarotene, α-tocopherol succinate) and imaging agents (dodecanethiol gold nanoparticles and 7-amino-4-methyl coumarin) based on diblock copolymer self assembly in the diffusion limited regime. Uniform particles with tunable sizes from 50-300 nm and long term stability are prepared at high concentrations of incorporated compound. The degree of agent loading is varied independently of particle size, allowing for precise control of system parameters.",

author = "M. Gindy and Prud'homme, {Robert Krafft}",

year = "2006",

month = dec,

day = "8",

language = "English (US)",

isbn = "0976798573",

volume = "2",

pages = "448--450",

booktitle = "2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings",

note = "2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings ; Conference date: 07-05-2006 Through 11-05-2006",

}

Gindy, M & Prud'homme, RK 2006, Preparation of aggregation stable block copolymer nanoparticles for simultaneous drug delivery and imaging. in 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings. vol. 2, pp. 448-450, 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings, Boston, MA, United States, 5/7/06.

TY - GEN

T1 - Preparation of aggregation stable block copolymer nanoparticles for simultaneous drug delivery and imaging

AU - Gindy, M.

AU - Prud'homme, Robert Krafft

PY - 2006/12/8

Y1 - 2006/12/8

N2 - We present a novel process for the simultaneous encapsulation of active pharmaceutical compounds (βcarotene, α-tocopherol succinate) and imaging agents (dodecanethiol gold nanoparticles and 7-amino-4-methyl coumarin) based on diblock copolymer self assembly in the diffusion limited regime. Uniform particles with tunable sizes from 50-300 nm and long term stability are prepared at high concentrations of incorporated compound. The degree of agent loading is varied independently of particle size, allowing for precise control of system parameters.

AB - We present a novel process for the simultaneous encapsulation of active pharmaceutical compounds (βcarotene, α-tocopherol succinate) and imaging agents (dodecanethiol gold nanoparticles and 7-amino-4-methyl coumarin) based on diblock copolymer self assembly in the diffusion limited regime. Uniform particles with tunable sizes from 50-300 nm and long term stability are prepared at high concentrations of incorporated compound. The degree of agent loading is varied independently of particle size, allowing for precise control of system parameters.

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M3 - Conference contribution

AN - SCOPUS:33845206846

SN - 0976798573

SN - 9780976798576

VL - 2

SP - 448

EP - 450

BT - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings

T2 - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings

Y2 - 7 May 2006 through 11 May 2006

ER -

Preparation of aggregation stable block copolymer nanoparticles for simultaneous drug delivery and imaging

Abstract

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All Science Journal Classification (ASJC) codes

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