Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile Rhesus monkeys

Christopher L. Coe, Marian Kramer, Boldizsár Czéh, Elizabeth Gould, Alison J. Reeves, Clemens Kirschbaum, Eberhard Fuchs

Research output: Contribution to journalArticle

338 Scopus citations

Abstract

Background: Early life stress, including during fetal development, has been hypothesized to predispose individuals to several illnesses and psychiatric disorders later in adulthood. Methods: To determine whether prenatal stress alters neural, hormonal, and behavioral processes in nonhuman primates, pregnant rhesus monkeys were acutely stressed on a daily basis for 25% of their 24-week gestation with an acoustical startle protocol. At 2 to 3 years of age, hippocampal volume, neurogenesis in the dentate gyrus, and cortisol levels were evaluated in the offspring generated from stressed and control pregnancies. Results: Prenatal stress, both early and late in pregnancy, resulted in a reduced hippocampal volume and an inhibition of neurogenesis in the dentate gyrus. These changes were associated with increased pituitary-adrenal activity, as reflected by higher cortisol levels after a dexamethasone suppression test, and also with behavioral profiles indicative of greater emotionality. Conclusions: These findings indicate that the prenatal environment can alter behavior, dysregulate neuroendocrine systems, and affect the hippocampal structure of primates in a persistent manner.

Original languageEnglish (US)
Pages (from-to)1025-1034
Number of pages10
JournalBiological Psychiatry
Volume54
Issue number10
DOIs
StatePublished - Nov 15 2003

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry

Keywords

  • Cortisol
  • Hippocampus
  • Monkey
  • Neurogenesis
  • Pregnancy
  • Stress

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