Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring

Ai Ing Lim, Taryn McFadden, Verena M. Link, Seong Ji Han, Rose Marie Karlsson, Apollo Stacy, Taylor K. Farley, Djalma S. Lima-Junior, Oliver J. Harrison, Jigar V. Desai, Michail S. Lionakis, Han Yu Shih, Heather A. Cameron, Yasmine Belkaid

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


The immune system has evolved in the face of microbial exposure. How maternal infection experienced at distinct developmental stages shapes the offspring immune system remains poorly understood. Here, we show that during pregnancy, maternally restricted infection can have permanent and tissue-specific impacts on offspring immunity. Mechanistically, maternal interleukin-6 produced in response to infection can directly impose epigenetic changes on fetal intestinal epithelial stem cells, leading to long-lasting impacts on intestinal immune homeostasis. As a result, offspring of previously infected dams develop enhanced protective immunity to gut infection and increased inflammation in the context of colitis. Thus, maternal infection can be coopted by the fetus to promote long-term, tissue-specific fitness, a phenomenon that may come at the cost of predisposition to inflammatory disorders.

Original languageEnglish (US)
Article numbereabf3002
Issue number6558
StatePublished - Aug 27 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


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