Prefrontal cortex guides context-appropriate responding during language production

John G. Kerns, Jonathan D. Cohen, V. Andrew Stenger, Cameron S. Carter

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Although language processing is thought to frequently require cognitive control, little is known about the cognitive and neural basis of the control of language. Here, we demonstrate that processing of context by the PFC plays an important role in the control of language comprehension and production. Using a missing letter paradigm and fMRI, we found that increased activation in the PFC (but not in posterior regions), while encoding and maintaining context information, predicted context-appropriate responses. Furthermore, greater selection demands increased activity during responding in the same regions engaged during the encoding and maintenance of context. Overall, as in other cognitive task domains, these results suggest that PFC context processing plays an important role in the control of language.

Original languageEnglish (US)
Pages (from-to)283-291
Number of pages9
JournalNeuron
Volume43
Issue number2
DOIs
StatePublished - Jul 22 2004

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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