Prediction and decoding of retinal ganglion cell responses with a probabilistic spiking model

Jonathan William Pillow, Liam Paninski, Valerie J. Uzzell, Eero P. Simoncelli, E. J. Chichilnisky

Research output: Contribution to journalArticle

228 Scopus citations

Abstract

Sensory encoding in spiking neurons depends on both the integration of sensory inputs and the intrinsic dynamics and variability of spike generation. We show that the stimulus selectivity, reliability, and timing precision of primate retinal ganglion cell (RGC) light responses can be reproduced accurately with a simple model consisting of a leaky integrate-and-fire spike generator driven by a linearly filtered stimulus, a postspike current, and a Gaussian noise current. We fit model parameters for individual RGCs by maximizing the likelihood of observed spike responses to a stochastic visual stimulus. Although compact, the fitted model predicts the detailed time structure of responses to novel stimuli, accurately capturing the interaction between the spiking history and sensory stimulus selectivity. The model also accounts for the variability in responses to repeated stimuli, even when fit to data from a single (nonrepeating) stimulus sequence. Finally, the model can be used to derive an explicit, maximum-likelihood decoding rule for neural spike trains, thus providing a tool for assessing the limitations that spiking variability imposes on sensory performance.

Original languageEnglish (US)
Pages (from-to)11003-11013
Number of pages11
JournalJournal of Neuroscience
Volume25
Issue number47
DOIs
StatePublished - Nov 23 2005

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Computational model
  • Decoding
  • Integrate and fire
  • Neural coding
  • Precision
  • Retinal ganglion cell
  • Spike timing
  • Spike trains
  • Variability

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