Predicting the location of the non-local contacts in α-synuclein

Fernando Bergasa-Caceres, Herschel A. Rabitz

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In this paper, the Sequential Collapse Model (SCM) for protein folding pathways is applied to investigate the location of the non-local contacts in the intrinsically disordered state of α-synuclein, a protein implicated in the onset and spreading of several serious neurodegenerative diseases. The model relies on the entropic cost of forming protein loops due to self-crowding effects, and the protein sequence to determine contact location and stability. It is found that the model predicts the existence of several possible non-local contacts, and the location of the non-local contacts is consistent with existing experimental evidence. The bearing of these findings on the pathogenic mechanism and its regulation is discussed.

Original languageEnglish (US)
Pages (from-to)1201-1208
Number of pages8
JournalBiochimica et Biophysica Acta - Proteins and Proteomics
Volume1866
Issue number12
DOIs
StatePublished - Dec 2018

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biophysics
  • Biochemistry
  • Molecular Biology

Keywords

  • Disordered proteins
  • Neurodegeneration
  • Non-local contacts
  • Parkinson
  • Protein dynamics
  • Synuclein

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