Abstract
We present a method for predicting protein-protein interactions mediated by the coiled-coil motif. When tested on interactions between nearly all human and yeast bZIP proteins, our method identifies 70% of strong interactions while maintaining that 92% of predictions are correct. Furthermore, cross-validation testing shows that including the bZIP experimental data significantly improves performance. Our method can be used to predict bZIP interactions in other genomes and is a promising approach for predicting coiled-coil interactions more generally.
Original language | English (US) |
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Pages (from-to) | R11 |
Journal | Genome biology |
Volume | 5 |
Issue number | 2 |
State | Published - 2004 |
All Science Journal Classification (ASJC) codes
- Ecology, Evolution, Behavior and Systematics
- Genetics
- Cell Biology