Membrane-assisted radiant panels have demonstrated the ability to provide sub dew-point cooling in humid climates without condensing air moisture. However, there has previously been no method of simulating the energy usage of a building that utilizes this method of cooling. This paper proposes a framework that allows a thermophysics model developed for membrane-assisted panels to operate within energy simulation software. Methods are developed that allows the thermophysics model to communicate with a TRNSYS environment. The framework is then used to predict the potential energy savings that could be obtained by implementing this technology in Singapore. It was found that this climate can benefit from the adoption of a cooling system that combines membrane-assisted radiant cooling with natural ventilation. The framework developed in this study will bring membrane-assisted radiant cooling closer to widespread implementation.