Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project

Kidney Precision Medicine Project

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Chronic kidney disease (CKD) and acute kidney injury (AKI) are heterogeneous syndromes defined clinically by serial measures of kidney function. Each condition possesses strong histopathologic associations, including glomerular obsolescence or acute tubular necrosis, respectively. Despite such characterization, there remains wide variation in patient outcomes and treatment responses. Precision medicine efforts, as exemplified by the Kidney Precision Medicine Project (KPMP), have begun to establish evolving, spatially anchored, cellular and molecular atlases of the cell types, states, and niches of the kidney in health and disease. The KPMP atlas provides molecular context for CKD and AKI disease drivers and will help define subtypes of disease that are not readily apparent from canonical functional or histopathologic characterization but instead are appreciable through advanced clinical phenotyping, pathomic, transcriptomic, proteomic, epigenomic, and metabolomic interrogation of kidney biopsy samples. This perspective outlines the structure of the KPMP, its approach to the integration of these diverse datasets, and its major outputs relevant to future patient care.

Original languageEnglish (US)
Pages (from-to)402-410
Number of pages9
JournalAmerican Journal of Kidney Diseases
Volume83
Issue number3
DOIs
StatePublished - Mar 2024

All Science Journal Classification (ASJC) codes

  • Nephrology

Keywords

  • Acute kidney injury
  • chronic kidney disease
  • precision medicine

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