Pre-metastatic niches: Organ-specific homes for metastases

Héctor Peinado, Haiying Zhang, Irina R. Matei, Bruno Costa-Silva, Ayuko Hoshino, Goncalo Rodrigues, Bethan Psaila, Rosandra N. Kaplan, Jacqueline F. Bromberg, Yibin Kang, Mina J. Bissell, Thomas R. Cox, Amato J. Giaccia, Janine T. Erler, Sachie Hiratsuka, Cyrus M. Ghajar, David Lyden

Research output: Contribution to journalReview articlepeer-review

1247 Scopus citations


It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

Original languageEnglish (US)
Pages (from-to)302-317
Number of pages16
JournalNature Reviews Cancer
Issue number5
StatePublished - May 1 2017

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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