PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism

Rachel R. Stine; Alexander P. Sakers; Tara TeSlaa; Megan Kissig; Zachary E. Stine; Chan Wook Kwon; Lan Cheng; Hee Woong Lim; Klaus H. Kaestner; Joshua D. Rabinowitz; Patrick Seale

doi:10.1016/j.stem.2019.08.017

PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism

Rachel R. Stine
, Alexander P. Sakers
, Tara TeSlaa
, Megan Kissig
, Zachary E. Stine
, Chan Wook Kwon
, Lan Cheng
, Hee Woong Lim
, Klaus H. Kaestner
, Joshua D. Rabinowitz
, Patrick Seale

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

Metabolic program expression and dependency vary along the length of the small intestine. PRDM16 transcriptionally regulates fatty acid oxidation (FAO), which is highest in the upper small intestine. Loss of Prdm16 reduces FAO, leading to apoptosis and diminished epithelial differentiation of progenitor cells in the upper intestine.

Original language	English (US)
Pages (from-to)	830-845.e8
Journal	Cell stem cell
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.stem.2019.08.017
State	Published - Dec 5 2019

All Science Journal Classification (ASJC) codes

Molecular Medicine
Genetics
Cell Biology

Keywords

PRDM16
apoptosis
differentiation
duodenum
fatty acid oxidation
intestinal stem cell
intestine
metabolism
transit amplifying cell

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10.1016/j.stem.2019.08.017

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title = "PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism",

abstract = "Metabolic program expression and dependency vary along the length of the small intestine. PRDM16 transcriptionally regulates fatty acid oxidation (FAO), which is highest in the upper small intestine. Loss of Prdm16 reduces FAO, leading to apoptosis and diminished epithelial differentiation of progenitor cells in the upper intestine.",

keywords = "PRDM16, apoptosis, differentiation, duodenum, fatty acid oxidation, intestinal stem cell, intestine, metabolism, transit amplifying cell",

author = "Stine, \{Rachel R.\} and Sakers, \{Alexander P.\} and Tara TeSlaa and Megan Kissig and Stine, \{Zachary E.\} and Kwon, \{Chan Wook\} and Lan Cheng and Lim, \{Hee Woong\} and Kaestner, \{Klaus H.\} and Rabinowitz, \{Joshua D.\} and Patrick Seale",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = dec,

day = "5",

doi = "10.1016/j.stem.2019.08.017",

language = "English (US)",

volume = "25",

pages = "830--845.e8",

journal = "Cell stem cell",

issn = "1934-5909",

publisher = "Cell Press",

number = "6",

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TY - JOUR

T1 - PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism

AU - Stine, Rachel R.

AU - Sakers, Alexander P.

AU - TeSlaa, Tara

AU - Kissig, Megan

AU - Stine, Zachary E.

AU - Kwon, Chan Wook

AU - Cheng, Lan

AU - Lim, Hee Woong

AU - Kaestner, Klaus H.

AU - Rabinowitz, Joshua D.

AU - Seale, Patrick

PY - 2019/12/5

Y1 - 2019/12/5

N2 - Metabolic program expression and dependency vary along the length of the small intestine. PRDM16 transcriptionally regulates fatty acid oxidation (FAO), which is highest in the upper small intestine. Loss of Prdm16 reduces FAO, leading to apoptosis and diminished epithelial differentiation of progenitor cells in the upper intestine.

AB - Metabolic program expression and dependency vary along the length of the small intestine. PRDM16 transcriptionally regulates fatty acid oxidation (FAO), which is highest in the upper small intestine. Loss of Prdm16 reduces FAO, leading to apoptosis and diminished epithelial differentiation of progenitor cells in the upper intestine.

KW - PRDM16

KW - apoptosis

KW - differentiation

KW - duodenum

KW - fatty acid oxidation

KW - intestinal stem cell

KW - intestine

KW - metabolism

KW - transit amplifying cell

UR - https://www.scopus.com/pages/publications/85075547356

UR - https://www.scopus.com/pages/publications/85075547356#tab=citedBy

U2 - 10.1016/j.stem.2019.08.017

DO - 10.1016/j.stem.2019.08.017

M3 - Article

C2 - 31564549

AN - SCOPUS:85075547356

SN - 1934-5909

VL - 25

SP - 830-845.e8

JO - Cell stem cell

JF - Cell stem cell

IS - 6

ER -

PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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