PRAD1 (cyclin D1): a parathyroid neoplasia gene on 11q13.

A. Arnold, T. Motokura, T. Bloom, C. Rosenberg, A. Bale, H. Kronenberg, J. Ruderman, M. Brown, H. G. Kim

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28 Scopus citations


Hyperparathyroidism is a central component of multiple endocrine neoplasia type 1 (MEN 1), and both sporadic and familial forms of parathyroid disease may share certain pathogenetic features. We recently identified a gene that is clonally rearranged with the PTH locus in a subset of sporadic parathyroid adenomas. This candidate oncogene, PRAD1 (previously D11S287), appears to contribute to parathyroid tumorigenesis in a fashion analogous to activation of C-MYC or BCL-2 by rearrangement with tissue-specific enhancers of the immunoglobulin genes in B-lymphoid neoplasia. The PRAD1 gene maps to 11q13 and has been linked to the BCL-1 breakpoint locus, although not to the most tightly linked MEN 1 markers, by pulsed field gel electrophoresis. PRAD1 may, in fact, be the long-sought BCL-1 lymphoma oncogene. PRAD1 encodes a novel type of cyclin protein and thus may normally function in controlling the cell cycle, perhaps through direct interaction with cdc2 or a related kinase. PRAD1's possible primary, or more likely secondary, involvement in the pathogenesis of MEN 1-related tumors is unknown and under investigation.

Original languageEnglish (US)
Pages (from-to)177-180
Number of pages4
JournalHenry Ford Hospital Medical Journal
Issue number3-4
StatePublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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