Practical synthesis of the calcimimetic agent, cinacalcet

Oliver R. Thiel; Charles Bernard; Wanda Tormos; Alan Brewin; Shuji Hirotani; Kazuo Murakami; Kenji Saito; Robert D. Larsen; Michael J. Martinelli; Paul J. Reider

doi:10.1016/j.tetlet.2007.11.030

Practical synthesis of the calcimimetic agent, cinacalcet

Oliver R. Thiel, Charles Bernard, Wanda Tormos, Alan Brewin, Shuji Hirotani, Kazuo Murakami, Kenji Saito, Robert D. Larsen, Michael J. Martinelli, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

A practical synthesis of cinacalcet (Sensipar^®, Mimpara^®) is described. The synthesis starts from readily available starting materials and relies on safe and practical reaction conditions. The sequence comprises three synthetic steps and only one isolation point. The overall yield for the sequence is 85%.

Original language	English (US)
Pages (from-to)	13-15
Number of pages	3
Journal	Tetrahedron Letters
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/j.tetlet.2007.11.030
State	Published - Jan 1 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2007.11.030

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title = "Practical synthesis of the calcimimetic agent, cinacalcet",

abstract = "A practical synthesis of cinacalcet (Sensipar{\textregistered}, Mimpara{\textregistered}) is described. The synthesis starts from readily available starting materials and relies on safe and practical reaction conditions. The sequence comprises three synthetic steps and only one isolation point. The overall yield for the sequence is 85%.",

author = "Thiel, {Oliver R.} and Charles Bernard and Wanda Tormos and Alan Brewin and Shuji Hirotani and Kazuo Murakami and Kenji Saito and Larsen, {Robert D.} and Martinelli, {Michael J.} and Reider, {Paul J.}",

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T1 - Practical synthesis of the calcimimetic agent, cinacalcet

AU - Thiel, Oliver R.

AU - Bernard, Charles

AU - Tormos, Wanda

AU - Brewin, Alan

AU - Hirotani, Shuji

AU - Murakami, Kazuo

AU - Saito, Kenji

AU - Larsen, Robert D.

AU - Martinelli, Michael J.

AU - Reider, Paul J.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - A practical synthesis of cinacalcet (Sensipar®, Mimpara®) is described. The synthesis starts from readily available starting materials and relies on safe and practical reaction conditions. The sequence comprises three synthetic steps and only one isolation point. The overall yield for the sequence is 85%.

AB - A practical synthesis of cinacalcet (Sensipar®, Mimpara®) is described. The synthesis starts from readily available starting materials and relies on safe and practical reaction conditions. The sequence comprises three synthetic steps and only one isolation point. The overall yield for the sequence is 85%.

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DO - 10.1016/j.tetlet.2007.11.030

M3 - Article

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EP - 15

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 1

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Practical synthesis of the calcimimetic agent, cinacalcet

Abstract

All Science Journal Classification (ASJC) codes

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