Practical synthesis of the calcimimetic agent, cinacalcet

Oliver R. Thiel, Charles Bernard, Wanda Tormos, Alan Brewin, Shuji Hirotani, Kazuo Murakami, Kenji Saito, Robert D. Larsen, Michael J. Martinelli, Paul J. Reider

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

A practical synthesis of cinacalcet (Sensipar®, Mimpara®) is described. The synthesis starts from readily available starting materials and relies on safe and practical reaction conditions. The sequence comprises three synthetic steps and only one isolation point. The overall yield for the sequence is 85%.

Original languageEnglish (US)
Pages (from-to)13-15
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Thiel, O. R., Bernard, C., Tormos, W., Brewin, A., Hirotani, S., Murakami, K., Saito, K., Larsen, R. D., Martinelli, M. J., & Reider, P. J. (2008). Practical synthesis of the calcimimetic agent, cinacalcet. Tetrahedron Letters, 49(1), 13-15. https://doi.org/10.1016/j.tetlet.2007.11.030