Practical synthesis of α-amino acids using cis-aminoindanol derived hippuric acid amide as a glycine enolate equivalent

Jaemoon Lee, Woo Baeg Choi, Joseph E. Lynch, R. P. Volante, P. J. Reider

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The use of cis-aminoindanol as a chiral auxiliary for asymmetric synthesis of α-amino acids is described. Alkylation of the chirally modified glycine enolate 2 with a number of alkyl halides in the presence of lithium chloride gave the corresponding alkylated product in 90 ~ 99% diastereoselectivity.

Original languageEnglish (US)
Pages (from-to)3679-3682
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number22
DOIs
StatePublished - May 28 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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