Practical routes toward the synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes

Lisa F. Frey, Karen Marcantonio, Doug E. Frantz, Jerry A. Murry, Richard D. Tillyer, Edward J.J. Grabowski, Paul J. Reider

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We recently required an efficient synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes. Several routes to these compounds were investigated resulting in efficient and practical procedures from readily available and inexpensive starting materials.

Original languageEnglish (US)
Pages (from-to)6815-6818
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number39
DOIs
StatePublished - Sep 24 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Keywords

  • α-methylbenzyl amine
  • Amination
  • Pyridine

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    Frey, L. F., Marcantonio, K., Frantz, D. E., Murry, J. A., Tillyer, R. D., Grabowski, E. J. J., & Reider, P. J. (2001). Practical routes toward the synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes. Tetrahedron Letters, 42(39), 6815-6818. https://doi.org/10.1016/S0040-4039(01)01428-9