Practical routes toward the synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes

Lisa F. Frey; Karen Marcantonio; Doug E. Frantz; Jerry A. Murry; Richard D. Tillyer; Edward J.J. Grabowski; Paul J. Reider

doi:10.1016/S0040-4039(01)01428-9

Practical routes toward the synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes

Lisa F. Frey, Karen Marcantonio, Doug E. Frantz, Jerry A. Murry, Richard D. Tillyer, Edward J.J. Grabowski, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We recently required an efficient synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes. Several routes to these compounds were investigated resulting in efficient and practical procedures from readily available and inexpensive starting materials.

Original language	English (US)
Pages (from-to)	6815-6818
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	39
DOIs	https://doi.org/10.1016/S0040-4039(01)01428-9
State	Published - Sep 24 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

Amination
Pyridine
α-methylbenzyl amine

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10.1016/S0040-4039(01)01428-9

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title = "Practical routes toward the synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes",

abstract = "We recently required an efficient synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes. Several routes to these compounds were investigated resulting in efficient and practical procedures from readily available and inexpensive starting materials.",

keywords = "Amination, Pyridine, α-methylbenzyl amine",

author = "Frey, {Lisa F.} and Karen Marcantonio and Frantz, {Doug E.} and Murry, {Jerry A.} and Tillyer, {Richard D.} and Grabowski, {Edward J.J.} and Reider, {Paul J.}",

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T1 - Practical routes toward the synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes

AU - Frey, Lisa F.

AU - Marcantonio, Karen

AU - Frantz, Doug E.

AU - Murry, Jerry A.

AU - Tillyer, Richard D.

AU - Grabowski, Edward J.J.

AU - Reider, Paul J.

PY - 2001/9/24

Y1 - 2001/9/24

N2 - We recently required an efficient synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes. Several routes to these compounds were investigated resulting in efficient and practical procedures from readily available and inexpensive starting materials.

AB - We recently required an efficient synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes. Several routes to these compounds were investigated resulting in efficient and practical procedures from readily available and inexpensive starting materials.

KW - Amination

KW - Pyridine

KW - α-methylbenzyl amine

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U2 - 10.1016/S0040-4039(01)01428-9

DO - 10.1016/S0040-4039(01)01428-9

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JO - Tetrahedron Letters

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ER -

Practical routes toward the synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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