Practical routes toward the synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes

Lisa F. Frey, Karen Marcantonio, Doug E. Frantz, Jerry A. Murry, Richard D. Tillyer, Edward J.J. Grabowski, Paul J. Reider

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We recently required an efficient synthesis of 2-halo- and 2-alkylamino-4-pyridinecarboxaldehydes. Several routes to these compounds were investigated resulting in efficient and practical procedures from readily available and inexpensive starting materials.

Original languageEnglish (US)
Pages (from-to)6815-6818
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number39
DOIs
StatePublished - Sep 24 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Keywords

  • α-methylbenzyl amine
  • Amination
  • Pyridine

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