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Practical asymmetric synthesis of aprepitant, a potent human NK-1 receptor antagonist, via a stereoselective Lewis acid-catalyzed trans acetalization reaction

  • Matthew M. Zhao
  • , James M. McNamara
  • , Guo Jie Ho
  • , Khateeta M. Emerson
  • , Zhiguo J. Song
  • , David M. Tschaen
  • , Karel M.J. Brands
  • , Ulf H. Dolling
  • , Edward J.J. Grabowski
  • , Paul J. Reider
  • , Ian F. Cottrell
  • , Michael S. Ashwood
  • , Brian C. Bishop

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Chemistry