Posterior error probabilities and false discovery rates: Two sides of the same coin

Lukas Käll; John D. Storey; Michael J. MacCoss; William Stafford Noble

doi:10.1021/pr700739d

Posterior error probabilities and false discovery rates: Two sides of the same coin

Lukas Käll
, John D. Storey
, Michael J. MacCoss
, William Stafford Noble

Research output: Contribution to journal › Review article › peer-review

251 Scopus citations

Abstract

A variety of methods have been described in the literature for assigning statistical significance to peptides identified via tandem mass spectrometry. Here, we explain how two types of scores, the q-value and the posterior error probability, are related and complementary to one another.

Original language	English (US)
Pages (from-to)	40-44
Number of pages	5
Journal	Journal of Proteome Research
Volume	7
Issue number	1
DOIs	https://doi.org/10.1021/pr700739d
State	Published - Jan 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemistry
Biochemistry

Keywords

False discovery rate
Peptide identification
Posterior error probability
Statistical significance
q-value

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10.1021/pr700739d

Cite this

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title = "Posterior error probabilities and false discovery rates: Two sides of the same coin",

abstract = "A variety of methods have been described in the literature for assigning statistical significance to peptides identified via tandem mass spectrometry. Here, we explain how two types of scores, the q-value and the posterior error probability, are related and complementary to one another.",

keywords = "False discovery rate, Peptide identification, Posterior error probability, Statistical significance, q-value",

author = "Lukas K{\"a}ll and Storey, \{John D.\} and MacCoss, \{Michael J.\} and Noble, \{William Stafford\}",

year = "2008",

month = jan,

doi = "10.1021/pr700739d",

language = "English (US)",

volume = "7",

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journal = "Journal of Proteome Research",

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T1 - Posterior error probabilities and false discovery rates

T2 - Two sides of the same coin

AU - Käll, Lukas

AU - Storey, John D.

AU - MacCoss, Michael J.

AU - Noble, William Stafford

PY - 2008/1

Y1 - 2008/1

N2 - A variety of methods have been described in the literature for assigning statistical significance to peptides identified via tandem mass spectrometry. Here, we explain how two types of scores, the q-value and the posterior error probability, are related and complementary to one another.

AB - A variety of methods have been described in the literature for assigning statistical significance to peptides identified via tandem mass spectrometry. Here, we explain how two types of scores, the q-value and the posterior error probability, are related and complementary to one another.

KW - False discovery rate

KW - Peptide identification

KW - Posterior error probability

KW - Statistical significance

KW - q-value

UR - https://www.scopus.com/pages/publications/38649129079

UR - https://www.scopus.com/pages/publications/38649129079#tab=citedBy

U2 - 10.1021/pr700739d

DO - 10.1021/pr700739d

M3 - Review article

C2 - 18052118

AN - SCOPUS:38649129079

SN - 1535-3893

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SP - 40

EP - 44

JO - Journal of Proteome Research

JF - Journal of Proteome Research

IS - 1

ER -

Posterior error probabilities and false discovery rates: Two sides of the same coin

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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