Posterior error probabilities and false discovery rates: Two sides of the same coin

Lukas Käll, John D. Storey, Michael J. MacCoss, William Stafford Noble

Research output: Contribution to journalReview article

179 Scopus citations

Abstract

A variety of methods have been described in the literature for assigning statistical significance to peptides identified via tandem mass spectrometry. Here, we explain how two types of scores, the q-value and the posterior error probability, are related and complementary to one another.

Original languageEnglish (US)
Pages (from-to)40-44
Number of pages5
JournalJournal of Proteome Research
Volume7
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Chemistry(all)

Keywords

  • False discovery rate
  • Peptide identification
  • Posterior error probability
  • Statistical significance
  • q-value

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