Posterior error probabilities and false discovery rates: Two sides of the same coin

Lukas Käll; John D. Storey; Michael J. MacCoss; William Stafford Noble

doi:10.1021/pr700739d

Posterior error probabilities and false discovery rates: Two sides of the same coin

Lukas Käll, John D. Storey, Michael J. MacCoss, William Stafford Noble

Research output: Contribution to journal › Review article › peer-review

234 Scopus citations

Abstract

A variety of methods have been described in the literature for assigning statistical significance to peptides identified via tandem mass spectrometry. Here, we explain how two types of scores, the q-value and the posterior error probability, are related and complementary to one another.

Original language	English (US)
Pages (from-to)	40-44
Number of pages	5
Journal	Journal of Proteome Research
Volume	7
Issue number	1
DOIs	https://doi.org/10.1021/pr700739d
State	Published - Jan 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemistry
Biochemistry

Keywords

False discovery rate
Peptide identification
Posterior error probability
Statistical significance
q-value

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10.1021/pr700739d

Cite this

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title = "Posterior error probabilities and false discovery rates: Two sides of the same coin",

abstract = "A variety of methods have been described in the literature for assigning statistical significance to peptides identified via tandem mass spectrometry. Here, we explain how two types of scores, the q-value and the posterior error probability, are related and complementary to one another.",

keywords = "False discovery rate, Peptide identification, Posterior error probability, Statistical significance, q-value",

author = "Lukas K{\"a}ll and Storey, {John D.} and MacCoss, {Michael J.} and Noble, {William Stafford}",

year = "2008",

month = jan,

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language = "English (US)",

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AU - Storey, John D.

AU - MacCoss, Michael J.

AU - Noble, William Stafford

PY - 2008/1

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KW - Peptide identification

KW - Posterior error probability

KW - Statistical significance

KW - q-value

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Posterior error probabilities and false discovery rates: Two sides of the same coin

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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