Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and disease

Rommel A. Mathias, Amanda J. Guise, Ileana M. Cristea

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Class IIa histone deacetylases (HDACs4, -5, -7, and -9) modulate the physiology of the human cardiovascular, musculoskeletal, nervous, and immune systems. The regulatory capacity of this family of enzymes stems from their ability to shuttle between nuclear and cytoplasmic compartments in response to signal-driven post-translational modification. Here, we review the current knowledge of modifications that control spatial and temporal histone deacetylase functions by regulating subcellular localization, transcriptional functions, and cell cycle-dependent activity, ultimately impacting on human disease. We discuss the contribution of these modifications to cardiac and vascular hypertrophy, myoblast differentiation, neuronal cell survival, and neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)456-470
Number of pages15
JournalMolecular and Cellular Proteomics
Volume14
Issue number3
DOIs
StatePublished - Mar 1 2015

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and disease'. Together they form a unique fingerprint.

  • Cite this