TY - JOUR
T1 - Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and disease
AU - Mathias, Rommel A.
AU - Guise, Amanda J.
AU - Cristea, Ileana M.
N1 - Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Class IIa histone deacetylases (HDACs4, -5, -7, and -9) modulate the physiology of the human cardiovascular, musculoskeletal, nervous, and immune systems. The regulatory capacity of this family of enzymes stems from their ability to shuttle between nuclear and cytoplasmic compartments in response to signal-driven post-translational modification. Here, we review the current knowledge of modifications that control spatial and temporal histone deacetylase functions by regulating subcellular localization, transcriptional functions, and cell cycle-dependent activity, ultimately impacting on human disease. We discuss the contribution of these modifications to cardiac and vascular hypertrophy, myoblast differentiation, neuronal cell survival, and neurodegenerative disorders.
AB - Class IIa histone deacetylases (HDACs4, -5, -7, and -9) modulate the physiology of the human cardiovascular, musculoskeletal, nervous, and immune systems. The regulatory capacity of this family of enzymes stems from their ability to shuttle between nuclear and cytoplasmic compartments in response to signal-driven post-translational modification. Here, we review the current knowledge of modifications that control spatial and temporal histone deacetylase functions by regulating subcellular localization, transcriptional functions, and cell cycle-dependent activity, ultimately impacting on human disease. We discuss the contribution of these modifications to cardiac and vascular hypertrophy, myoblast differentiation, neuronal cell survival, and neurodegenerative disorders.
UR - http://www.scopus.com/inward/record.url?scp=84924284481&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924284481&partnerID=8YFLogxK
U2 - 10.1074/mcp.O114.046565
DO - 10.1074/mcp.O114.046565
M3 - Review article
C2 - 25616866
AN - SCOPUS:84924284481
SN - 1535-9476
VL - 14
SP - 456
EP - 470
JO - Molecular and Cellular Proteomics
JF - Molecular and Cellular Proteomics
IS - 3
ER -