TY - JOUR
T1 - Porters versus rowers
T2 - A unified stochastic model of motor proteins
AU - Leibler, S.
AU - Huse, D. A.
PY - 1993
Y1 - 1993
N2 - We present a general phenomenological theory for chemical to mechanical energy transduction by motor enzymes which is based on the classical 'tight- coupling' mechanism. The associated minimal stochastic model takes explicitly into account both ATP hydrolysis and thermal noise effects. It provides expressions for the hydrolysis rate and the sliding velocity, as functions of the ATP concentration and the number of motor enzymes. It explains in a unified way many results of recent in vitro motility assays. More importantly, the theory provides a natural classification scheme for the motors: it correlates the biochemical and mechanical differences between 'porters' such as cellular kinesins or dyneins, and 'rowers' such as muscular myosins or flagellar dyneins.
AB - We present a general phenomenological theory for chemical to mechanical energy transduction by motor enzymes which is based on the classical 'tight- coupling' mechanism. The associated minimal stochastic model takes explicitly into account both ATP hydrolysis and thermal noise effects. It provides expressions for the hydrolysis rate and the sliding velocity, as functions of the ATP concentration and the number of motor enzymes. It explains in a unified way many results of recent in vitro motility assays. More importantly, the theory provides a natural classification scheme for the motors: it correlates the biochemical and mechanical differences between 'porters' such as cellular kinesins or dyneins, and 'rowers' such as muscular myosins or flagellar dyneins.
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U2 - 10.1083/jcb.121.6.1357
DO - 10.1083/jcb.121.6.1357
M3 - Article
C2 - 8509455
AN - SCOPUS:0027273502
VL - 121
SP - 1357
EP - 1368
JO - Journal of Cell Biology
JF - Journal of Cell Biology
SN - 0021-9525
IS - 6
ER -