Porters versus rowers: A unified stochastic model of motor proteins

S. Leibler, D. A. Huse

Research output: Contribution to journalArticle

194 Scopus citations

Abstract

We present a general phenomenological theory for chemical to mechanical energy transduction by motor enzymes which is based on the classical 'tight- coupling' mechanism. The associated minimal stochastic model takes explicitly into account both ATP hydrolysis and thermal noise effects. It provides expressions for the hydrolysis rate and the sliding velocity, as functions of the ATP concentration and the number of motor enzymes. It explains in a unified way many results of recent in vitro motility assays. More importantly, the theory provides a natural classification scheme for the motors: it correlates the biochemical and mechanical differences between 'porters' such as cellular kinesins or dyneins, and 'rowers' such as muscular myosins or flagellar dyneins.

Original languageEnglish (US)
Pages (from-to)1357-1368
Number of pages12
JournalJournal of Cell Biology
Volume121
Issue number6
DOIs
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • Cell Biology

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