Polymer-protected liposomes: Association of hydrophobically-modified PEG with liposomes

Debra T. Auguste, Robert K. Prud'homme, Patrick L. Ahl, Paul Meers, Joachim Kohn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

We demonstrate the impact of cooperative interactions on liposome protection by incorporating multiple hydrophobic sites on poly(ethylene glycol) (PEG) polymers. Our hydrophobically-modified PEGs (HMPEGs) are comb-graft copolymers with precisely alternating, monodisperse PEG blocks (MW= 6, 12, or 35 kDa), bonded to C18 stearylamide hydrophobes. Cooperativity is controlled by varying the extent of oligomerization at a constant ratio of PEG to stearlyamide. The association of polymer with liposomes increases with the degree of oligomerization; equilibrium constants for 6 kDa PEG increases from 6.1±0.8 (mg/m2)/(mg/ml) for 3 loops to 78.1112.2 (mg/m 2)/(mg/ml) for 13 loops. In addition, HMPEG6k-DP3 (with three 6 kDa loops) results in superior, irreversible protection from complement protein binding than DSPE-PEG5k after 12 hours.

Original languageEnglish (US)
Title of host publicationPolymeric Drug Delivery I
Subtitle of host publicationParticulate Drug Carriers
PublisherAmerican Chemical Society
Pages95-120
Number of pages26
ISBN (Print)0841239185, 9780841239180
DOIs
StatePublished - 2006

Publication series

NameACS Symposium Series
Volume923
ISSN (Print)0097-6156

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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    Auguste, D. T., Prud'homme, R. K., Ahl, P. L., Meers, P., & Kohn, J. (2006). Polymer-protected liposomes: Association of hydrophobically-modified PEG with liposomes. In Polymeric Drug Delivery I: Particulate Drug Carriers (pp. 95-120). (ACS Symposium Series; Vol. 923). American Chemical Society. https://doi.org/10.1021/bk-2006-0923.ch008