TY - JOUR
T1 - Point prevalence surveys of antimicrobial use among eight neonatal intensive care units in India
T2 - 2016
AU - Gandra, Sumanth
AU - Alvarez-Uria, Gerardo
AU - Murki, Srinivas
AU - Singh, Sanjeev K.
AU - Kanithi, Ravishankar
AU - Jinka, Dasaratha R.
AU - Chikkappa, Ashok K.
AU - Subramanian, Sreeram
AU - Sharma, Anita
AU - Dharmapalan, Dhanya
AU - Kandraju, Hemasree
AU - Vasudevan, Anil Kumar
AU - Tunga, Onkaraiah
AU - Akula, Akhila
AU - Hsia, Yingfen
AU - Sharland, Mike
AU - Laxminarayan, Ramanan
N1 - Publisher Copyright:
© 2018 The Author(s)
PY - 2018/6
Y1 - 2018/6
N2 - Background: Information about antimicrobial use is scarce and poorly understood among neonatal intensive care units (NICUs) in India. In this study, we describe antimicrobial use in eight NICUs using four point prevalence surveys (PPSs). Methods: As part of the Global Antimicrobial Resistance, Prescribing, and Efficacy in Neonates and Children (GARPEC) study, one-day, cross-sectional, hospital-based PPSs were conducted four times between 1 February 2016 and 28 February 2017 in eight NICUs. Using a standardized web-based electronic data entry form, detailed data were collected for babies on antimicrobials. Results: A total of 403 babies were admitted to NICUs across all survey days, and 208 (51.6%) were prescribed one or more antimicrobials. Among 208 babies, 155 (74.5%) were prescribed antimicrobials for treatment of an active infection. Among 155 babies with an active infection, treatment was empiric in 109 (70.3%). Sepsis (108, 49.1%) was the most common reason for prescribing antimicrobials. Amikacin (17%) followed by meropenem (12%) were the two most commonly prescribed antimicrobials. For community-acquired sepsis, piperacillin-tazobactam (17.5%) was the most commonly prescribed drug. A combination of ampicillin and gentamicin was prescribed in only two babies (5%). Conclusions: The recommended first-line antimicrobial agents, ampicillin and gentamicin, were rarely prescribed in Indian NICUs for community acquired neonatal sepsis.
AB - Background: Information about antimicrobial use is scarce and poorly understood among neonatal intensive care units (NICUs) in India. In this study, we describe antimicrobial use in eight NICUs using four point prevalence surveys (PPSs). Methods: As part of the Global Antimicrobial Resistance, Prescribing, and Efficacy in Neonates and Children (GARPEC) study, one-day, cross-sectional, hospital-based PPSs were conducted four times between 1 February 2016 and 28 February 2017 in eight NICUs. Using a standardized web-based electronic data entry form, detailed data were collected for babies on antimicrobials. Results: A total of 403 babies were admitted to NICUs across all survey days, and 208 (51.6%) were prescribed one or more antimicrobials. Among 208 babies, 155 (74.5%) were prescribed antimicrobials for treatment of an active infection. Among 155 babies with an active infection, treatment was empiric in 109 (70.3%). Sepsis (108, 49.1%) was the most common reason for prescribing antimicrobials. Amikacin (17%) followed by meropenem (12%) were the two most commonly prescribed antimicrobials. For community-acquired sepsis, piperacillin-tazobactam (17.5%) was the most commonly prescribed drug. A combination of ampicillin and gentamicin was prescribed in only two babies (5%). Conclusions: The recommended first-line antimicrobial agents, ampicillin and gentamicin, were rarely prescribed in Indian NICUs for community acquired neonatal sepsis.
KW - Antimicrobial use
KW - India
KW - NICU
KW - Neonates
KW - Point prevalence survey
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U2 - 10.1016/j.ijid.2018.03.017
DO - 10.1016/j.ijid.2018.03.017
M3 - Article
C2 - 29608958
AN - SCOPUS:85046036623
SN - 1201-9712
VL - 71
SP - 20
EP - 24
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -