@inbook{0f34ca642324468899cdecb52489a47b,
title = "Pleiotropic roles of AEG-1/MTDH/LYRIC in breast cancer",
abstract = "Since the initial discovery of AEG-1/MTDH/LYRIC, our appreciation for this novel protein's involvement in cancer has increased dramatically over the past few years. AEG-1/MTDH/LYRIC is a key functional target of the 8q22 genomic gain that is frequently observed in poor-prognosis breast cancer, where it plays a dual role in promoting chemoresistance and metastasis. Beyond this, growing evidence from clinical research indicates a strong correlation between AEG-1/MTDH/LYRIC expression and the pathogenesis of a large spectrum of cancer types, and multiple studies employing in vitro cell culture systems and in vivo xenograft models have revealed multifaceted roles of AEG-1/MTDH/LYRIC in cancer biology, including tumor cell proliferation, apoptosis, angiogenesis, and autophagy. With increasing mechanistic understanding of AEG-1/MTDH/LYRIC, discovery of agents that can block AEG-1/MTDH/LYRIC and its regulated pathways will be beneficial to cancer patients with aberrant expression of AEG-1/MTDH/LYRIC.",
keywords = "AEG-1, Breast cancer, Chemoresistance, Metadherin, Metastasis",
author = "Liling Wan and Yibin Kang",
year = "2013",
doi = "10.1016/B978-0-12-401676-7.00004-8",
language = "English (US)",
series = "Advances in Cancer Research",
publisher = "Academic Press Inc.",
pages = "113--134",
booktitle = "Advances in Cancer Research",
address = "United States",
}