TY - JOUR
T1 - Planar cell polarity
T2 - global inputs establishing cellular asymmetry
AU - Aw, Wen Yih
AU - Devenport, Danelle
N1 - Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Many tissues develop coordinated patterns of cell polarity that align with respect to the tissue axes. This phenomenon refers to planar cell polarity (PCP) and is controlled by multiple conserved PCP modules. A key feature of PCP proteins is their asymmetric localization within the tissue plane, whose orientation is guided by global directional cues. Here, we highlight current models and recent findings on the role of tissue-level gradients, local organizer signals, and mechanical forces in establishing the global patterns of PCP.
AB - Many tissues develop coordinated patterns of cell polarity that align with respect to the tissue axes. This phenomenon refers to planar cell polarity (PCP) and is controlled by multiple conserved PCP modules. A key feature of PCP proteins is their asymmetric localization within the tissue plane, whose orientation is guided by global directional cues. Here, we highlight current models and recent findings on the role of tissue-level gradients, local organizer signals, and mechanical forces in establishing the global patterns of PCP.
UR - http://www.scopus.com/inward/record.url?scp=84994128847&partnerID=8YFLogxK
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U2 - 10.1016/j.ceb.2016.08.002
DO - 10.1016/j.ceb.2016.08.002
M3 - Review article
C2 - 27576155
AN - SCOPUS:84994128847
SN - 0955-0674
VL - 44
SP - 110
EP - 116
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -