TY - JOUR
T1 - Pindolol increases extracellular 5-HT while inhibiting serotonergic neuronal activity
AU - Fornal, Casimir A.
AU - Martín, Francisco J.
AU - Mendlin, Anna
AU - Metzler, Christine W.
AU - Bjorvatn, Bjørn
AU - Jacobs, Barry L.
N1 - Funding Information:
This work was supported by a grant from the National Institute of Mental Health (MH-23433). F.J.M. was a recipient of a FPI Post-doctoral Fellowship from the Spanish Government. B.B. was a visiting research scientist from the Department of Physiology, University of Bergen, Bergen, Norway. The authors thank Wyeth Research for kindly providing WAY-100635.
PY - 1999/7/21
Y1 - 1999/7/21
N2 - The effects of pindolol, a beta-adrenoceptor blocker/putative 5-hydroxytryptamine (5-HT)(1A/1B) antagonist, on both the single-unit activity of serotonergic neurons in the dorsal raphe nucleus (DRN) and extracellular 5-HT levels in the caudate nucleus, were examined in freely moving cats. Administration of (±)-pindolol (1 and 10 mg/kg, s.c.) decreased neuronal activity and increased 5-HT levels in a dose- and time-dependent manner. The subsequent administration of WAY-100635 {(N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide} (0.2 mg/kg, s.c.), a selective 5-HT(1A) receptor antagonist, blocked pindolol-induced neuronal suppression and potentiated 5-HT output. These results indicate that pindolol may be acting at the level of the nerve terminal to increase 5-HT. Copyright (C) 1999 Elsevier Science B.V.
AB - The effects of pindolol, a beta-adrenoceptor blocker/putative 5-hydroxytryptamine (5-HT)(1A/1B) antagonist, on both the single-unit activity of serotonergic neurons in the dorsal raphe nucleus (DRN) and extracellular 5-HT levels in the caudate nucleus, were examined in freely moving cats. Administration of (±)-pindolol (1 and 10 mg/kg, s.c.) decreased neuronal activity and increased 5-HT levels in a dose- and time-dependent manner. The subsequent administration of WAY-100635 {(N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide} (0.2 mg/kg, s.c.), a selective 5-HT(1A) receptor antagonist, blocked pindolol-induced neuronal suppression and potentiated 5-HT output. These results indicate that pindolol may be acting at the level of the nerve terminal to increase 5-HT. Copyright (C) 1999 Elsevier Science B.V.
KW - 5-HT (5-hydroxytryptamine), extracellular
KW - 5-HT(1A) autoreceptor
KW - Microdialysis
KW - Pindolol
KW - Serotonergic neuronal activity
KW - Serotonin
KW - WAY-100635
UR - http://www.scopus.com/inward/record.url?scp=0032769795&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032769795&partnerID=8YFLogxK
U2 - 10.1016/S0014-2999(99)00430-6
DO - 10.1016/S0014-2999(99)00430-6
M3 - Article
C2 - 10456429
AN - SCOPUS:0032769795
SN - 0014-2999
VL - 377
SP - 187
EP - 191
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -