Physics of cancer propagation: A game theory perspective

Chris Cleveland; David Liao; Robert Austin

doi:10.1063/1.3699043

Physics of cancer propagation: A game theory perspective

Chris Cleveland, David Liao, Robert Austin

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

This is a theoretical paper which examines at a game theoretical perspective the dynamics of cooperators and cheater cells under metabolic stress conditions and high spatial heterogeneity. Although the ultimate aim of this work is to understand the dynamics of cancer tumor evolution under stress, we use a simple bacterial model to gain fundamental insights into the progression of resistance to drugs under high competition and stress conditions.

Original language	English (US)
Article number	011202
Journal	AIP Advances
Volume	2
Issue number	1
DOIs	https://doi.org/10.1063/1.3699043
State	Published - Mar 2012

All Science Journal Classification (ASJC) codes

General Physics and Astronomy

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10.1063/1.3699043

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title = "Physics of cancer propagation: A game theory perspective",

abstract = "This is a theoretical paper which examines at a game theoretical perspective the dynamics of cooperators and cheater cells under metabolic stress conditions and high spatial heterogeneity. Although the ultimate aim of this work is to understand the dynamics of cancer tumor evolution under stress, we use a simple bacterial model to gain fundamental insights into the progression of resistance to drugs under high competition and stress conditions.",

author = "Chris Cleveland and David Liao and Robert Austin",

note = "Funding Information: The project described was supported by the National Science Foundation and the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health. We thank Ted Cox, Terry Hwa, Nigel Goldenfeld, Guillaume Lambert, Jonas Pedersen, Susan Rosenberg. Saurabh Vyawahare and Andrew Bergman for useful discussions. ",

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Physics of cancer propagation: A game theory perspective

Abstract

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