Photoredox-catalyzed deoxyfluorination of activated alcohols with Selectfluor®

María González-Esguevillas, Javier Miró, Jenna L. Jeffrey, David W.C. MacMillan

Research output: Contribution to journalArticle

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Abstract

Herein we disclose a deoxyfluorination of alcohols with an electrophilic fluorine source via visible-light photoredox catalysis. This radical-mediated C–F coupling is capable of fluorinating secondary and tertiary alcohols efficiently, complementing previously reported nucleophilic deoxyfluorination protocols.

Original languageEnglish (US)
Pages (from-to)4222-4227
Number of pages6
JournalTetrahedron
Volume75
Issue number32
DOIs
StatePublished - Aug 9 2019

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Keywords

  • Deoxyfluorination
  • Fluoroalkanes
  • Oxalates
  • Photoredox

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