Abstract
A facile and efficient method for the α-trifluoromethylation of carbonyl compounds and enolsilanes has been accomplished through application of a photoredox catalysis strategy. A one-flask procedure for the direct α-trifluoromethylation and α-perfluoroalkylation of ketone, amide, and ester substrates as well as silylketene acetals is described (see scheme).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6119-6122 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 50 |
| Issue number | 27 |
| DOIs | |
| State | Published - Jun 27 2011 |
All Science Journal Classification (ASJC) codes
- Catalysis
- General Chemistry
Keywords
- enolsilanes
- photoredox catalysis
- α-perfluoroalkylation
- α-trifluoromethylation
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