Photoredox catalysis: A mild, operationally simple approach to the synthesis of α-trifluoromethyl carbonyl compounds

Phong V. Pham; David A. Nagib; David W.C. MacMillan

doi:10.1002/anie.201101861

Photoredox catalysis: A mild, operationally simple approach to the synthesis of α-trifluoromethyl carbonyl compounds

Phong V. Pham
, David A. Nagib
, David W.C. MacMillan

Research output: Contribution to journal › Article › peer-review

440 Scopus citations

Abstract

A facile and efficient method for the α-trifluoromethylation of carbonyl compounds and enolsilanes has been accomplished through application of a photoredox catalysis strategy. A one-flask procedure for the direct α-trifluoromethylation and α-perfluoroalkylation of ketone, amide, and ester substrates as well as silylketene acetals is described (see scheme).

Original language	English (US)
Pages (from-to)	6119-6122
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	27
DOIs	https://doi.org/10.1002/anie.201101861
State	Published - Jun 27 2011

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry

Keywords

enolsilanes
photoredox catalysis
α-perfluoroalkylation
α-trifluoromethylation

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10.1002/anie.201101861

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abstract = "A facile and efficient method for the α-trifluoromethylation of carbonyl compounds and enolsilanes has been accomplished through application of a photoredox catalysis strategy. A one-flask procedure for the direct α-trifluoromethylation and α-perfluoroalkylation of ketone, amide, and ester substrates as well as silylketene acetals is described (see scheme).",

keywords = "enolsilanes, photoredox catalysis, α-perfluoroalkylation, α-trifluoromethylation",

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year = "2011",

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AU - Pham, Phong V.

AU - Nagib, David A.

AU - MacMillan, David W.C.

PY - 2011/6/27

Y1 - 2011/6/27

N2 - A facile and efficient method for the α-trifluoromethylation of carbonyl compounds and enolsilanes has been accomplished through application of a photoredox catalysis strategy. A one-flask procedure for the direct α-trifluoromethylation and α-perfluoroalkylation of ketone, amide, and ester substrates as well as silylketene acetals is described (see scheme).

AB - A facile and efficient method for the α-trifluoromethylation of carbonyl compounds and enolsilanes has been accomplished through application of a photoredox catalysis strategy. A one-flask procedure for the direct α-trifluoromethylation and α-perfluoroalkylation of ketone, amide, and ester substrates as well as silylketene acetals is described (see scheme).

KW - enolsilanes

KW - photoredox catalysis

KW - α-perfluoroalkylation

KW - α-trifluoromethylation

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UR - https://www.scopus.com/pages/publications/79959504347#tab=citedBy

U2 - 10.1002/anie.201101861

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EP - 6122

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 27

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Photoredox catalysis: A mild, operationally simple approach to the synthesis of α-trifluoromethyl carbonyl compounds

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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