TY - JOUR
T1 - Photoredox catalysis
T2 - A mild, operationally simple approach to the synthesis of α-trifluoromethyl carbonyl compounds
AU - Pham, Phong V.
AU - Nagib, David A.
AU - MacMillan, David W.C.
PY - 2011/6/27
Y1 - 2011/6/27
N2 - A facile and efficient method for the α-trifluoromethylation of carbonyl compounds and enolsilanes has been accomplished through application of a photoredox catalysis strategy. A one-flask procedure for the direct α-trifluoromethylation and α-perfluoroalkylation of ketone, amide, and ester substrates as well as silylketene acetals is described (see scheme).
AB - A facile and efficient method for the α-trifluoromethylation of carbonyl compounds and enolsilanes has been accomplished through application of a photoredox catalysis strategy. A one-flask procedure for the direct α-trifluoromethylation and α-perfluoroalkylation of ketone, amide, and ester substrates as well as silylketene acetals is described (see scheme).
KW - enolsilanes
KW - photoredox catalysis
KW - α-perfluoroalkylation
KW - α-trifluoromethylation
UR - http://www.scopus.com/inward/record.url?scp=79959504347&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959504347&partnerID=8YFLogxK
U2 - 10.1002/anie.201101861
DO - 10.1002/anie.201101861
M3 - Article
C2 - 21604347
AN - SCOPUS:79959504347
SN - 1433-7851
VL - 50
SP - 6119
EP - 6122
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 27
ER -