Photoredox catalysis: A mild, operationally simple approach to the synthesis of α-trifluoromethyl carbonyl compounds

Phong V. Pham, David A. Nagib, David W.C. MacMillan

Research output: Contribution to journalArticle

355 Scopus citations

Abstract

A facile and efficient method for the α-trifluoromethylation of carbonyl compounds and enolsilanes has been accomplished through application of a photoredox catalysis strategy. A one-flask procedure for the direct α-trifluoromethylation and α-perfluoroalkylation of ketone, amide, and ester substrates as well as silylketene acetals is described (see scheme).

Original languageEnglish (US)
Pages (from-to)6119-6122
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number27
DOIs
StatePublished - Jun 27 2011

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Keywords

  • enolsilanes
  • photoredox catalysis
  • α-perfluoroalkylation
  • α-trifluoromethylation

Fingerprint Dive into the research topics of 'Photoredox catalysis: A mild, operationally simple approach to the synthesis of α-trifluoromethyl carbonyl compounds'. Together they form a unique fingerprint.

  • Cite this